Troubled by the predicted downfall of the world, reporter Tsutomu Goto begins investigating a spirit medium experiment being conducted at the labs of the University of East Asia. The experiment is aimed towards reaching the long deceased Nostradamus in hopes of shedding light on his prophecies for the end of the world. Unfortunately, the experiment fails to make contact with the French prophet, but research is interrupted by an ominous UFO hanging over Japan...

A sequel for Prophecies of Nostradamus was planned by producer Tomoyuki Tanaka as far back as 1974, the year Toshio Masuda's film was released in theaters. Literally titled The Great Prophecies of Nostradamus II: Fear of the Great Devil and set for a 1975 debut, the proposed project was to reunite most of the principal staff from the first, including director Masuda, writer Toshio Yasumi, special effects director Teruyoshi Nakano and producer Osamu Tanaka. Writer Masato Ide, who helped write the screenplays for several Akira Kurosawa productions such as Red Beard (1965) and Ran (1985), was also attached to the project.

Sadly, not much is known of the plot, beyond the spirit experiments, the UFO and the reporter role, whose character was to be named after author Tsutomu Goto who wrote the novel the first film was based on. Whether the project had any continuity with its predecessor, though, is unknown.

Not surprisingly, the project never saw the light of day, which could most likely be credited to the controversy that amounted around Prophecies of Nostradamus that eventually led to a self imposed ban on the 1974 film and most likely sealed the fate of this sequel.