In order to hurt Mecha-King Ghidorah, players have to first attack one of its heads, to do this players will have to be situated in the center (vertically) of the stage when attacking. After being hit in the head, Mecha-King Ghidorah will stand motionless, with its cockpit flashing red, for almost two seconds. Its during these two seconds that the player will have to strike at Mecha-King Ghidorah's chest to actually hurt the Kaiju. After two seconds have passed, Mecha-King Ghidorah's heads will lunge forward, attempting to bite the player, before it goes back to firing projectiles. The perfect time to hit Mecha-King Ghidorah is right after he bites but before he has a chance to start firing at the player again.

After, successfully, hitting Mecha-King Ghidorah in the chest six times, one of Mecha-King Ghidorah's organic heads will self-destruct and drop four Rage Up power ups. After hitting Mecha-King Ghidorah an additional eight times in the chest, his other organic head will self-destruct and drop another four Rage Up power ups. If Mecha-King Ghidorah is hit another eight times, his central head will go wild and start firing off projectiles at an accelerated rate. Hit Mecha-King Ghidorah another eight times to finally destroy him.

• Godzilla: Use Godzilla's Horizontal Claw (L Button, then A Button) to attack one of Mecha-King Ghidorah's heads. Because Godzilla's Horizontal Claw is a lunging move, it should be executed while Godzilla is in the middle of the stage (horizontally). Once Mecha-King Ghidorah's chest is blinking, follow up with two Diagonal Kicks (L Button, then A Button), following the second Diagonal Kick, run away from Mecha-King Ghidorah to avoid its bite attack. After Mecha-King Ghidorah has finished trying to bite Godzilla, Horizontal Claw one of his heads again and repeat the above strategy until he is defeated. If your rage meter is full, and Godzilla is low on life, use Godzilla's Regeneration (A + B Buttons) Rage Attack to heal him.
• King Ghidorah: Use Ghidorah's Wing Sheer Blast Jump (L Button, then A Button) to attack one of Mecha-King Ghidorah's heads. The fact that Wing Sheer Blast Jump is a aerial projectile makes this move the most effective in the game at hitting Mecha-King Ghidorah's head. Once Mecha-King Ghidorah's chest is blinking, follow up with two Swooping Talon Scratches (L Button, then A Button), immediately following the second one, move to the bottom portion of the level to avoid Mecha-King Ghidorah's bite. The Swooping Talon Scratches can hit Mecha-King Ghidorah up to three times each, if done correctly, but take longer to perform than most other moves, which is why King Ghidorah can't retreat diagonally like other kaiju. After Mecha-King Ghidorah has finished attempting to bite King Ghidorah, Wing Sheer Blast Jump his central head again and repeat the above strategy until he is beaten. Because King Ghidorah's Swooping Talon Scratches is so effective, players should ignore his Rage Attacks.
• Rodan: Use Rodan's Finger Dive (L Button, then A Button) to attack one of Mecha-King Ghidorah's heads. Once his chest is blinking, follow up with two Finger Dives aimed at Mecha-King Ghidorah's chest, before retreating in time to avoid the bite. After Mecha-King Ghidorah has finished attempting to bite Rodan, Finger Dive his central head again and repeat the above strategy until he is destroyed. Rodan's Rage Attacks aren't useful here compared to the Finger Dive, which hits the chest twice, and should be ignored.
• Mechagodzilla: Use Mechagodzilla's Diagonal Jet Kick (L Button, then B Button) to attack one of Mecha-King Ghidorah's heads. Once his chest is blinking, follow up with two Rotary Tail Swipes (L Button, then A Button) against Mecha-King Ghidorah, before retreating in time far enough away to escape Mecha-King Ghidorah bite. After Mecha-King Ghidorah has finished attempting to bite Mechagodzilla, Diagonal Jet Kick one of his heads again and repeat the above strategy until he is defeated. If Mechagodzilla has a full Rage Meter, you can attack Mecha-King Ghidorah, while his chest is blinking, with Mechagodzilla's Steam Cooldown, which will strike four times (the same number as two Rotary Tail Swipes) and heal Mechagodzilla.
• Mothra: Use Mothra's Headbutt (A Button), while jumping in the air, to hit one of Mecha-King Ghidorah's heads. Because Mothra's headbutt is a lunging move, it should be executed while Mothra is in the middle of the stage (horizontally). Once Mecha-King Ghidorah's chest is blinking, follow up with two more aerial Headbutts aimed at Mecha-King Ghidorah, before retreating in time to avoid the bite. Immediately after Mecha-King Ghidorah attempts to bite Mothra, strike him with another aerial Headbutt and then repeat the above strategy. If Mothra has a full Rage Meter, then, while Mecha-King Ghidorah's chest is blinking, release Wing Lightning (L Button, then A + B Buttons) as close to his chest as possible. If done correctly it should hit him at least eight times.
• Megalon: Use Megalon's Horizontal Drill Punch (L Button, then A Button) to hit one of Mecha-King Ghidorah's heads. Because Megalon's Horizontal Drill Punch is a lunging move, it should be executed while Megalon is in the middle of the stage (horizontally). Follow up the attack, while Mecha-King Ghidorah's chest is blinking, with two Diagonal Drill Punches (L Button, then B Button) before retreating out of the range of Mecha-King Ghidorah's bite. After Mecha-King Ghidorah attempts to bite Megalon, strike him with another Horizontal Drill Punch and then repeat the above strategy. Unfortunately, none of Megalon's Rage Attacks are useful here, and should be ignored.

Jump
- Mecha-King Ghidorah leaps into the air and then, violently, slams into the ground, damaging the player if they are standing.

Bite
- After Mecha-King Ghidorah goes back on the offensive when his chest is done blinking, he will reach out with his heads in an attempt to bite the opponent. If successful, Mecha-King Ghidorah will shake the player in mid air, while still biting them, before throwing the player across the screen.

Fireball
- One of Mecha-King Ghidorah's organic heads lets loose a fireball aimed at the player.

Green Fireball
- Mecha-King Ghidorah's mechanic head lets loose with a green fireball aimed at the player. This move is identical to Fireball, except in appearance.

Blue Energy Blasts
- Mecha-King Ghidorah unleashes three blue blasts of energy aimed at the player.

Red Energy Blasts
- Mecha-King Ghidorah fires three red blasts of energy aimed at the player. This move is identical to Blue Energy Blasts, except in appearance.

Tri-Attack
- Mecha-King Ghidorah's three heads each unleash a fireball. This move can only be done when all three of Mecha-King Ghidorah's heads are intact.

Ultimate Attack
- After losing his two organic heads and being hit an additional eight times, Mecha-King Ghidorah will let lose with his most powerful attack which comprises of six blasts, red and blue, from his remaining head.